Cefonex

Cefonex combines the potent third-generation cephalosporin Cefoperazone with the β-lactamase inhibitor Sulbactam to deliver enhanced antibacterial efficacy against resistant organisms.
This synergistic combination provides broad-spectrum coverage for both Gram-positive and Gram-negative infections, making it a dependable choice in moderate to severe bacterial infections.

• Broad Spectrum Coverage – Active against β-lactamase producing bacteria
• Synergistic Action – Dual mechanism enhances efficacy
• Hospital-Grade Therapy – Effective in both community and hospital-acquired infections
• Reliable Clinical Tolerance – Excellent safety profile for prolonged use

• Cefoperazone acts by inhibiting bacterial cell wall synthesis, leading to cell lysis and death.

• Sulbactam inactivates β-lactamase enzymes, thereby protecting Cefoperazone from degradation and restoring its activity against resistant strains.
  Together, they provide enhanced bactericidal activity against a wide range of pathogens.

• Dual Antibacterial Strength: Combines a cephalosporin and β-lactamase inhibitor.

• Effective Against Resistant Strains: Protects against β-lactamase-mediated resistance.

• Versatile Use: Suitable for a wide range of hospital and community infections.

• Proven Clinical Safety: Excellent tolerance and patient compliance.

Cefonex is indicated in the treatment of infections caused by susceptible microorganisms, such as:

• Respiratory tract infections (including pneumonia and bronchitis)

• Urinary tract infections

• Intra-abdominal infections

• Biliary tract infections

• Skin and soft tissue infections

• Septicemia and bacteremia

• Gynecological infections

• Bone and joint infections

• Use cautiously in patients with penicillin or cephalosporin hypersensitivity.

• Monitor liver and renal functions during prolonged therapy.

• Dosage adjustment may be required in patients with hepatic dysfunction.

• Avoid alcohol consumption during therapy and up to 72 hours after last dose to prevent a disulfiram-like reaction (flushing, nausea, vomiting).

• Discontinue immediately if any allergic reaction or anaphylaxis occurs.

• Use under the supervision of a qualified healthcare professional only.

Generally well-tolerated.
Mild effects may include nausea, diarrhea, headache, or pain at the injection site.
Occasionally, elevated liver enzymes, rash, or allergic reactions may occur.
Rarely, prolonged use may cause superinfections or changes in blood counts.

• Adults: 2–4 g per day divided every 12 hours by IV or IM route.

• Severe infections: Up to 8–12 g per day may be used under medical supervision.

• Route: Intravenous (IV) or Intramuscular (IM) injection.

• Reconstitution: Dissolve in sterile water for injection or 0.9% sodium chloride before administration.

• Adjust dose in hepatic dysfunction or renal-hepatic impairment.