Pangen 40

Pangen 40 is a proton pump inhibitor (PPI) indicated for the management of acid-related gastrointestinal disorders.
It provides rapid, sustained acid suppression, offering effective relief in GERD, peptic ulcers, erosive esophagitis, and stress-related mucosal damage in critically ill patients.
With its excellent tolerability and once-daily dosing convenience, Pangen 40 is a reliable solution for both hospital and outpatient settings.

• Fast Acid Control – Provides rapid relief from gastric hyperacidity
• Mucosal Protection – Promotes healing of ulcers and erosions
• Hospital-Grade Reliability – Ideal for post-surgical and ICU patients
• Well-Tolerated – Safe even for prolonged therapy

Pantoprazole selectively inhibits the H⁺/K⁺ ATPase enzyme system in gastric parietal cells, blocking the final step of acid production.
This leads to long-lasting suppression of gastric acid secretion, providing effective symptom relief and ulcer healing.

• Fast Onset of Action: Provides rapid suppression of gastric acid.

• Sustained Effect: Maintains low acid levels for up to 24 hours.

• Flexible Use: Suitable for both emergency and maintenance therapy.

• Excellent Tolerability: Minimal drug interactions and side effects.

Pangen 40 is indicated in the treatment of:

• Gastroesophageal Reflux Disease (GERD)

• Peptic Ulcer Disease (gastric and duodenal ulcers)

• Erosive Esophagitis

• Zollinger-Ellison Syndrome and other hypersecretory conditions

• Stress-related mucosal damage in critically ill patients

• Prophylaxis of acid aspiration in surgical procedures

• Administer only via intravenous route under medical supervision.

• Use with caution in patients with severe hepatic impairment.

• Prolonged use may increase risk of vitamin B₁₂ deficiency or hypomagnesemia.

• May slightly increase susceptibility to gastrointestinal infections (Clostridium difficile).

• Do not mix with other IV drugs or infusions.

• Evaluate periodically if used for long-term acid suppression therapy.

Generally well-tolerated.
Mild side effects may include headache, nausea, flatulence, or diarrhea.
Occasionally, mild injection-site irritation or dizziness.
Rarely, prolonged therapy may cause low magnesium or vitamin B₁₂ levels.

• Adults: 40 mg once daily by slow intravenous injection or infusion.

• In severe conditions: May be increased to 80 mg/day as per physician’s advice.

• Route: Intravenous (IV) only; not for intramuscular use.

• Reconstitution: Dissolve contents in 10 mL sterile saline or compatible IV fluid; use immediately after preparation.